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September 13, 1930


Author Affiliations

From the Emory University Hospital.

JAMA. 1930;95(11):780-787. doi:10.1001/jama.1930.02720110016006

The red marrow of the bones makes erythrocytes, granular leukocytes and platelets. In agranulocytosis, the factory that makes the granulocytes has shut down. The life of this cell in the normal conditions of health is three days or more,1 and from three to five days by other evidences. Therefore should the red marrow stop manufacturing them for three, four or five days, they would after that time totally disappear from the blood stream. This is apparently what happens. In our patient there is evidence that it did happen. The factory divisions of the marrow that make the erythrocytes and the platelets seem to continue to work at approximately their normal output. There is little if any evidence that the granulocytes are formed normally in the marrow and destroyed in the blood stream. On the contrary, there is much evidence that the myelocytic function of the marrow stops and that

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