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September 13, 1930


JAMA. 1930;95(11):798-799. doi:10.1001/jama.1930.02720110034011

The conception of the relationship of vitamin A to disease has been modified gradually since the discovery of this vitamin, and recent investigations have indicated that other changes may be anticipated. Stepp1 observed in 1909 that mice failed to grow when on a diet consisting of bread and milk which had been extracted with alcohol-ether. About the same time Osborne and Mendel discovered a substance in butter fat in the absence of which growth would not occur. In 1912 McCollum confirmed Osborne and Mendel's observations and discovered the same substance in egg yolk fats, calling it "unidentified dietary factor fatsoluble-A." Funk coined the term "vitamin," and since then this substance has been known as vitamin A. At first it was known as the antirachitic and antixerophthalmic vitamin. Since the discovery of vitamin D, rickets has not been closely associated with vitamin A. Recently Wolbach and Howe,2 feeding rats

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