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Gross anatomic research as ordinarily carried out through dissection with the naked eye and natural light, has certain limitations. For instance, it is not possible, under such conditions, to follow up the course of afferent nerves in the heart muscles, the walls of the stomach, or the bladder. The study of finer ramifications of the nerve fibers, their connections with the ganglion cells and other structures is left to the histologist. The latter, however, is able to study only small areas and has to resort to reconstruction methods in order to bring out the topography of the finer nerve structures. Areas that are inaccessible to the gross anatomist and do not actually belong to the domain of the histologist are named by Worobiew macro-microscopic. In this book, which is merely an introduction, he describes the methods used in "macromicroscopic" studies by himself and his pupils. Dissecting is done with very
Methodik der Untersuchungen von Nervenelementen des makround makro-mikroskopischen Gebietes.. JAMA. 1926;86(21):1647–1648. doi:10.1001/jama.1926.02670470055035