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September 13, 1930


JAMA. 1930;95(11):807-808. doi:10.1001/jama.1930.02720110043019

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Effect of Sympathetic Stimulation on the Leukocyte Count  Addressing recently the Société médicale des hôpitaux, J. Tinel and J. Henrion sought to adduce arguments in support of a theory that they hold, which is not entirely new, that the leukocyte count is controlled by the various actions of the two parts of the sympathetic system. They cited instances in which tobacco and phenobarbital had produced almost constantly leukopenia, affecting chiefly the neutrophil polymorphonuclears, the proportion of which may be lowered by from 56 to 36 per cent in heavy smokers, with monocytosis of the large and medium-sized mononuclears, together with eosinophilia. These phenomena may be reproduced at will if tobacco is indulged in to excess and will disappear on its discontinuance. Phenobarbital acts in the same manner. Tinel says that by comparing these results with the action of the pharmaceutic agents on the sympathetic nerves one may assume that the

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