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September 13, 1930


Author Affiliations

Research Institute of Cutaneous Medicine, Philadelphia.

JAMA. 1930;95(11):815-816. doi:10.1001/jama.1930.02720110051027

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To the Editor:  —The use of parenteral injections in human beings of the products of pathogenic microbes with the object of inducing immune states against such organisms is still in its infancy. Notable examples are the phytines (fungus products), streptococcus scarlatinal and erysipelas toxins, and Klebs-Loeffler bacillary toxin. One of the newest is perhaps the products of Staphylococcus aureus.It has been known for many years that Staphylococcus aureus and albus produce toxins. Von Lingelsheim in 1899 showed that the filtrates of Staphylococcus aureus had a necrotizing effect on rabbit skin, subsequently confirmed by others and especially by Parker in 1924, whose work actually paved the way for measuring the toxicity of filtrates from different strains.The first attempt, so far as we are aware, to induce an immune state in man with the filtrable products of Staphylococcus pyogenes-aureus was made in 1926. The results were read in Philadelphia, May

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