[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address 54.163.129.96. Please contact the publisher to request reinstatement.
[Skip to Content Landing]
Views 443
Citations 0
Comment & Response
July 28, 2015

Maternal Diabetes and Autism in Offspring—Reply

Author Affiliations
  • 1Department of Research and Evaluation, Kaiser Permanente Southern California, Pasadena
JAMA. 2015;314(4):407. doi:10.1001/jama.2015.7256

In Reply Mr Zitser raises an important question about whether a history of comorbidity should have been adjusted for in our investigation of intrauterine exposure to maternal diabetes during pregnancy and risk of ASD in offspring. We argue that a history of comorbidity should have been adjusted for because the main focus of our study was maternal glucose during pregnancy, with the exposure categorized as preexisting diabetes, gestational diabetes mellitus diagnosed at 26 weeks’ gestation or less or diagnosed at more than 26 weeks’ gestation, or no diabetes. As shown in Table 2 in the article, compared with unexposed children, the crude hazard ratio (HR) for ASD in children whose mothers had preexisting diabetes (HR, 1.59) was almost identical to the crude HR in children whose mothers had gestational diabetes diagnosed at 26 weeks’ gestation or less (HR, 1.63).

First Page Preview View Large
First page PDF preview
First page PDF preview
×