The old story of the bile pigments within the body has been entirely rewritten. The new presentation has not been the result of a single stroke of experimental good fortune or scientific intuition, but has been developed chapter by chapter through substantial investigation, mostly in American laboratories. Experimental technic has played a significant part in the success of the newer discoveries. They were not the incidental by-product of the clinic.
The liver has lost its extreme dominance in relation to the genesis of the bile pigments. Reviewing the subject little more than a year ago, Rich1 of Johns Hopkins University felt justified in stating that we are unable to speak with certainty concerning the exact rôle of the liver in normal bile pigment formation except so far as we are sure that the epithelial liver cell is not necessary for the formation of the pigment. The latter was thus
THE FORMATION OF BILE PIGMENT. JAMA. 1926;86(26):1985. doi:10.1001/jama.1926.02670520029009