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Syphilis exerts a malevolent influence on the tissue of the adult. When transmitted it distorts the orderly development of the tissues of the descendant either directly in the first generation or indirectly in the second. Sometimes the disease itself is transmitted and sometimes merely a dystrophy or dysfunction probably due to corruption of the glands of internal secretion. The more remote the transmission or the less virulent its origin, the more commonly does the disease manifest itself by a lability of the organism in the form of a dystrophy or dysfunction. Keen observers insist that the nervous tissue becomes involved almost with the appearance of the chancre. This view is not found in their writings but is secreted in the private explanations of many competent neurologists called on to treat the frequently early nervous signs. As a specific nervous condition one sees in inherited syphilis such well defined entities as
L'hérédo-syphilis mentale.. JAMA. 1930;95(13):957. doi:10.1001/jama.1930.02720130053033