Effort expended with one objective in view often proves important in a different and frequently unforeseen direction. The possibility for such a circumstance is greater, the more complex the system to which the initial adjustment is applied. In the history of the development of biochemistry, many cases in point have arisen. An instance in which this principle is generally applicable is the possible clinical significance of the data derived from the many recent serious investigations of nutritional anemia. These studies have been largely on experimental animals; whether nutritional anemia in animals has a counterpart in human anemias is a question that has not been definitely answered. However, disappointing as it may seem that the results from experimental anemia are difficult to translate into clinical experience, they have served the unsought purpose of stimulating interest in several unusual chemical elements the nutritional significance of which has not heretofore been fully appreciated.
COBALT AND NUTRITION. JAMA. 1933;100(8):579. doi:10.1001/jama.1933.02740080043013