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October 4, 1930


JAMA. 1930;95(14):1022-1023. doi:10.1001/jama.1930.02720140044012

Hemochromatosis is a rare but readily recognized disease characterized clinically by bronzing of the skin, by ascites and other symptoms of cirrhosis of the liver, and by diabetes mellitus. Anatomically it is characterized by the widespread deposition of pigment in the tissues and organs of the body including the skin, to which the visible bronzing is due; by continuous destruction of liver cells and their replacement by connective tissue, to which the manifestations of cirrhosis are due; and by destruction of acinous and islet cells of the pancreas and their replacement by connective tissue, to which the symptoms of diabetes are due. The more exact modern knowledge of the condition dates from the classic presentation of the subject by von Recklinghausen, who in 1889 gave a thorough description of the disease and demonstrated the presence in the tissues of two kinds of pigment. One of these, which is iron-free and

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