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October 4, 1930


JAMA. 1930;95(14):1023-1024. doi:10.1001/jama.1930.02720140045013

The introduction of irradiated ergosterol in various forms, such as viosterol in oil or cod liver oil supplemented with viosterol, into modern therapy has raised many questions of practical as well as scientific importance. The uncertainty as to the possible toxicity of an agent so uniquely potent as irradiated ergosterol awakened misgivings regarding the desirability of advocating its widespread use. These misgivings prompted the limitation of the recommended dosage within modest bounds. However, it has been repeatedly demonstrated that doses a hundred or even a thousand times those that bring about cures of rickets may be used before disaster ensues. The dreaded specters of hypercalcemia, with its dire effects on the arteries, and of hyperphosphatemia were presently dispelled. The pendulum of dosage had swung so far in the direction of caution that it now seems advisable to increase somewhat the concentration of viosterol in oil and in cod liver oil

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