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October 4, 1930


JAMA. 1930;95(14):1031-1032. doi:10.1001/jama.1930.02720140053021

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Titrable Forms of the Bacilli Typhosus and Paratyphosus  Studies on the filtrable forms of various micro-organisms are overthrowing many conceptions of hygiene that were regarded as definitely established, so that the whole epidemiology of many infectious diseases has to be restudied. Typhoid and paratyphoid bacilli normally do not pass through porcelain filters. Under the influence of the bacteriophage, they take on a filtrable form and later, when introduced into the organism, they again assume their bacillary form. Mr. P. Haudroy found these invisible forms in the stools and in the blood of typhoid patients, and in polluted waters. These invisible forms in polluted waters transmit typhoid and paratyphoid fevers, and the absence of bacilli in such waters will give henceforth no sense of security. The same conclusion applies to germ carriers, for they may remain for a long time infectious, though they present no visible bacilli, provided they still harbor

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