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July 31, 1926


JAMA. 1926;87(5):327-328. doi:10.1001/jama.1926.02680050037016

The physiologist thinks of the pylorus primarily as a barrier marking the boundary between the seat of digestion in an acid medium and a region enriched with alkaline secretions, apparently subject to delicate control mechanisms of some sort. To the clinician it is a region frequently the seat of neoplasms and other structural as well as functional abnormalities. Pyloric obstruction and pylorospasm are common phenomena of medical interest and remedial concern. The fact that the pylorus is not continually patent is the starting point for theories of its function. It has repeatedly been noted in The Journal4 that the long acclaimed acid control of the sphincter is not tenable in the light of accumulating evidence. In essence the theory postulates, first, that the discharge of foodstuffs is "occasional," and, secondly, that this irregularity is determined by the time necessary for the acid to reach the proper reaction on the

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