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The author has studied and described the comparative histology, evolution and function of the lymphoid tissue. He defines the state of reaction (l'état réactionnel) as the accumulation of lymphocytes in tissues that show no other abnormality; he considers it a stage intermediate between the normal and the pathologic. He found such accumulations of lymphocytes in animals living in insanitary surroundings. He was also able to induce such lymphocytic reactions experimentally in rats by keeping them under unhygienic conditions or by exposing them to the irritating fumes of formaldehyde or of turpentine. Histologically the reactional state is characterized by a hyperplasia of the lymphoid tissues with no other signs of inflammation. The author reviews the anatomy of the lymphoid tissue in the pharynx, thymus, intestine, appendix, lymph nodes and spleen. This part of the monograph is needlessly prolonged and emphasized, since the facts are presented in elementary works on histology. After
L'état réactionnel: Évolution du tissu lymphoïde en réaction.. JAMA. 1933;100(10):769. doi:10.1001/jama.1933.02740100063039