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To the Editor:
—Attention has recently been drawn (Brooks, Matilda M.: Am. J. Physiol. 102:145 [Oct.] 1932. Geiger, J. C.: The Journal, Dec. 3, 1932, p. 1944. Hanzlik, P. J., ibid., February 4, p. 357. Eddy, N. B.: J. Pharmacol. & Exper. Therap. 41:449 [April] 1931. Hug, Enrique: Compt. rend. Soc. de biol. 111:519, 1932) to the earlier observation (Sahlin, B.: Skandinav. Arch. f. Physiol. 47:284, 1925) that the injection of methylene blue antagonizes the toxicity of hydrocyanic acid administered to animals and man. The explanation of this protective action of the dye is of interest from several points of view: its bearing on the mechanism of tissue respiration, the possibility that other more effective antidotal agents may be found, and the limit to which protection against hydrocyanic acid poisoning may be expected from the dye and similarly acting substances. The purpose of this communication is
Wendel WB. METHYLENE BLUE AND CYANIDE POISONING. JAMA. 1933;100(13):1054–1055. doi:10.1001/jama.1933.02740130058029