[Skip to Content]
[Skip to Content Landing]
April 1, 1933


Author Affiliations

St. Louis. Instructor in Biological Chemistry, Washington University School of Medicine

JAMA. 1933;100(13):1054-1055. doi:10.1001/jama.1933.02740130058029

This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables.


To the Editor:  —Attention has recently been drawn (Brooks, Matilda M.: Am. J. Physiol. 102:145 [Oct.] 1932. Geiger, J. C.: The Journal, Dec. 3, 1932, p. 1944. Hanzlik, P. J., ibid., February 4, p. 357. Eddy, N. B.: J. Pharmacol. & Exper. Therap. 41:449 [April] 1931. Hug, Enrique: Compt. rend. Soc. de biol. 111:519, 1932) to the earlier observation (Sahlin, B.: Skandinav. Arch. f. Physiol. 47:284, 1925) that the injection of methylene blue antagonizes the toxicity of hydrocyanic acid administered to animals and man. The explanation of this protective action of the dye is of interest from several points of view: its bearing on the mechanism of tissue respiration, the possibility that other more effective antidotal agents may be found, and the limit to which protection against hydrocyanic acid poisoning may be expected from the dye and similarly acting substances. The purpose of this communication is

First Page Preview View Large
First page PDF preview
First page PDF preview