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October 18, 1930


Author Affiliations


JAMA. 1930;95(16):1175-1178. doi:10.1001/jama.1930.02720160035011

Venoclysis is a term which I1 have employed to designate a method for the biologic and continuous administration of physiologic and therapeutic solutions directly into the blood stream. The rate of the flow is regulated so that it will enter the blood stream in accordance with an estimated rate of delivery and distribution. Clinical experiences seem to indicate that for the adult individual this rate is approximately 200 cc. of fluid an hour, or a range of between 4,000 and 5,000 cc. of fluid in the twenty-four hours. The estimate of physiologic tolerance has been based, first, on the fact that patients receiving this amount of fluid at the rate here indicated are free from chills and sudden elevation of temperature, which regularly occur when solutions are suddenly or rapidly introduced directly into the circulation. Secondly, the rise in blood sugar is never more than 200 and then only

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