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October 18, 1930


Author Affiliations

New York
Department of Pediatrics, Cornell University Medical College and New York Nursery and Child's Hospital

JAMA. 1930;95(16):1195-1196. doi:10.1001/jama.1930.02720160055028

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To the Editor:  —Since 1910, when von Dungern and Hirschfeld proved that the inheritance of the group-specific substances proceeded according to Mendel's law, the medicolegal aspects of this phenomenon have been recognized and utilized. In its simplest form, they showed that the agglutinogen A or B does not appear in the blood of the infant unless it is present in at least one of the parents. Their contention has since been corroborated by Ottenberg and others in large series of cases.In a study, "Iso-agglutinins in the New-Born" (Am. J. Dis. Child.36:54 [July] 1928), I presented the results of an investigation which added to the available evidence that the iso-agglutinins found in the cord blood and in the circulation of the new-born infant are in large part derived from the mother as a consequence probably of placental transmission. The initial iso-agglutinins may disappear but in the course of

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