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To the Editor:
—In an editorial in The Journal, March 11, entitled "The Erythrocyte Sedimentation Rate in Disease," it is stated that, in spite of many studies, the theory behind variations in the sedimentation rate remains clouded. There is, however, a general agreement among many observers, e. g., Fåhraeus (Physiol. Rev.9:241 [April] 1929), Starlinger (Biochem. Ztschr.114: 129, 1921), Westergren (Ztschr. f. d. ges. exper. Med.75: 668, 1931) and Gram (Arch. Int. Med.28:312 [Sept.] 1921), that an increase in the sedimentation rate is chiefly due to an increase in the fibrinogen or globulins of the blood. Although other factors also play a rôle, such as hydremia, anemia, erythrocytosis and color index (Rourke and Plass: J. Clin. Investigation7:365 (Aug.) 1929. Rourke and Ernstene, ibid.8:545 [June] 1930. Bendien and Snapper: Biochem. Ztschr.235: 14, 1931. Ohno: Ztschr. f. d. ges. exper. Med.52
Reimann HA. ERYTHROCYTE SEDIMENTATION RATE IN DISEASE. JAMA. 1933;100(16):1276-1277. doi:10.1001/jama.1933.02740160060031