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Mrs. N. J., aged 41, American, a housewife, consulted me, Aug. 5, 1932, on account of an evanescent, extremely itchy eruption which affected her lower extremities, especially her thighs. It began sometime during the month of May, 1932, and was always worse at night and about the time of waking in the morning. The patient stated that about two hours after retiring she would generally wake up on account of the intensity of the itch, and at that time fairly good sized welts would be present on her legs, and they would persist during the night and at times after she got up in the morning. Later during the day the itching would subside, only to return and repeat the cycle during the night.
General examination revealed nothing of importance, except the remnants of some scratch marks and a few indefinite wheals, sufficient, however, to make the diagnosis of urticaria.
Hollander L. URTICARIA DUE TO SENNA LEAVES. JAMA. 1933;100(17):1329-1330. doi:10.1001/jama.1933.27420170002009a