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JAMA Clinical Evidence Synopsis
August 18, 2015

Isotonic vs Hypotonic Intravenous Fluids for Hospitalized Children

Author Affiliations
  • 1Department of General Medicine, Royal Children’s Hospital, Melbourne, Australia
  • 2Murdoch Childrens Research Institute, Melbourne, Australia
  • 3Department of Pediatrics, University of Melbourne, Melbourne, Australia
JAMA. 2015;314(7):720-721. doi:10.1001/jama.2015.7918

Clinical Question  Is isotonic fluid associated with a lower incidence of hyponatremia when compared with hypotonic fluid for maintenance intravenous fluid therapy in children?

Bottom Line  Compared with hypotonic fluid, isotonic fluid is associated with a lower incidence of hyponatremia, without evidence of an increase in adverse outcomes.