The behavior of the heart in hyperthyroidism presents a number of interesting problems for the surgeon and the internist. Thyrotoxic damage to the heart muscle was recognized by Kocher years ago. Now it is quite generally accepted that thyroid hyperactivity is capable of producing disturbances of cardiac function ranging from relatively innocent tachycardia to grave myocardial damage. One third of all arrhythmias seen by him in Munich, according to F. Mueller, were thyrogenous. Romberg1 assigns an important place to the thyrogenous factor in the etiology of arrhythmia. The action of thyroxine here is spent on the sinus area. Tachycardia of thyrogenous origin may assume the paroxysmal form.
Julius Bauer2 said some years ago that sudden death in hyperthyroidism is frequently the result of transition of fibrillation from auricles to ventricles. Goodpasture,3 Loos and other authors described myocardial changes in connection with thyrotoxicosis. Fatty degeneration, brown atrophy, round
DISTURBANCES OF THE HEART AS INDICATION FOR SURGICAL INTERVENTION IN HYPERTHYROIDISM. JAMA. 1933;100(18):1430–1431. doi:10.1001/jama.1933.02740180052011