[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address Please contact the publisher to request reinstatement.
[Skip to Content Landing]
Views 622
Citations 0
Comment & Response
August 25, 2015

Opioid Dependence Treatment in the Emergency Department—Reply

Author Affiliations
  • 1Department of Internal Medicine, Yale School of Medicine, New Haven, Connecticut
  • 2Department of Emergency Medicine, Yale School of Medicine, New Haven, Connecticut
JAMA. 2015;314(8):835. doi:10.1001/jama.2015.8527

In Reply Dr Swartz provides an opportunity to discuss the fundamental principles of clinical research and opioid dependence treatment that guided our study. Clinical trial design involves selecting a primary, clinically important outcome at a point in time.1 Our primary outcome was engagement in treatment at 30 days. We chose engagement in treatment as the primary outcome because it is associated with decreased criminal activity, HIV transmission, and mortality.24

First Page Preview View Large
First page PDF preview
First page PDF preview