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This booklet contains a collection of short articles and reprints of articles published in nonspecialist journals, all dealing with what the author considers an important objective sign of early epilepsy; namely, white spots. He finds them in epilepsy, and he believes that they aid greatly in the detection of that disease; indeed, he is firmly convinced that a knowledge of them and the epileptic vasomotor reactions is necessary for its accurate diagnosis. He thus describes the spots: "They are observable on the arm, the back of the hands, or the face; are chronic in location, and evidently caused by vasoconstriction; that is, the blood vessels of the skin contract locally and squeeze out their blood content, thus making the white spot." The author speaks of an incipient stage of epilepsy, without convulsive seizures, that quite frequently progresses unrecognized, with no diagnosis ventured until recurrent convulsions occur. It is in this
The White Spots of Epilepsy and Other Phases of the Disease.. JAMA. 1926;87(12):962-963. doi:10.1001/jama.1926.02680120072041