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September 25, 1926


Author Affiliations

From the Department of Pathology and Bacteriology, University of Tennessee College of Medicine.

JAMA. 1926;87(13):996-1002. doi:10.1001/jama.1926.02680130010003

This study of the etiology of granuloma inguinale was undertaken for the purpose of determining the nature, transmissibility and differential diagnosis of the causative agent and the period of incubation of the infection.

Granuloma inguinale is manifested by a granulomatous proliferation and ulceration of the cutaneous and subcutaneous tissues about the inguinal region, often extending down to involve the external genitals (fig. 1).

HISTORY  The literature dealing with the etiology of granuloma inguinale is limited and inconclusive. Castellani1 states that Conyers and Daniels, in 1895, first satisfactorily described granuloma inguinale, and it has since been considered a definite clinical and pathologic disease entity. Donovan,2 in 1905, observed oval bodies measuring from 0.5 to 2 microns in diameter in macrophages, either scattered or in small compact groups, in smears made from granulomatous lesions of this disease, and expressed doubt as to their location in the animal kingdom. In subsequent

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