Aspergillosis of the lungs is a disease caused by an exceedingly common mold, Aspergillus fumigatus. It is a disease which clinically and pathologically so closely resembles tuberculosis that it usually escapes recognition and is diagnosed as tuberculosis. This mistake may even be made at necropsies; for the ulcerations of the bronchi, the pneumonic and emphysematous areas, the cavities and pleurisies are much the same in one disease as in the other.
There is a common belief that this mold is purely saprophytic; that it can live only on preexisting lesions in the lungs; that it cannot attack living tissues because it has no primary pathogenic powers. To show its pathogenic properties, nine rabbits were inoculated intravenously with varying doses of spores, from a pure culture of Aspergillus fumigatus furnished by Dr. Thom of Washington.
In March, 1926, the pathologist of the Flagler Hospital, St. Augustine, Fla., inoculated three rabbits. One
LAPHAM ME. ASPERGILLOSIS OF THE LUNGS AND ITS ASSOCIATION WITH TUBERCULOSIS. JAMA. 1926;87(13):1031-1033. doi:10.1001/jama.1926.02680130045012