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September 25, 1926


JAMA. 1926;87(13):1038-1039. doi:10.1001/jama.1926.02680130052017

Among the acute gastro-intestinal disturbances of infancy, the condition frequently designated as severe intestinal intoxication is well recognized as of serious moment. True cholera infantum has long been rated among the maladies for which a high mortality is frankly admitted. In disorders in which a definite causation is recognized, it is sometimes possible to use somewhat specific methods of treatment or at least to apply therapeutic procedures on a reasonably rational basis. The management of intestinal intoxication has, by contrast, rarely followed comprehensive plans in the past; the treatment has been guided by the symptoms as they arise and has included liberal use of fluid both enterally and parenterally, intravenous administration of alkali to combat assumed acidosis, and the supply of milk mixtures supposed to be more or less specific for diarrhea. For such a seemingly haphazard routine, our incomplete knowledge of the pathogenesis of the disorder must bear a

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