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The "path to rational therapy," in the opinion of the editor of this book, lies through the quantitative application of specifically acting bodies in accordance with pharmacologic principles. This symposium, held at Speyerershof, an institution devoted to the treatment of chronic internal diseases, is an attempt at exact study of dosage and the recording of the effects of medicines on man. In his introduction, Fraenkel stresses the point that internists should have as sharp indications and definite technic for their interventions as surgeons have for operations. In the present development of knowledge, a small, well studied group of medicines is much more desirable than a large number poorly understood. It is better for the physician to give nothing, when he is uncertain as to what to give, than to give a little medicine that is inactive or to give too much. Paul Martini gives a brief exposition of the mathematical
Der Weg zur rationellen Therapie.. JAMA. 1933;100(20):1634. doi:10.1001/jama.1933.02740200068041