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November 1, 1930


JAMA. 1930;95(18):1348-1349. doi:10.1001/jama.1920.02720180042015

The greatly accentuated interest that has been displayed in medical circles within the last few years toward the problems of the anemias, and particularly toward pernicious anemia, has brought the blood cells into renewed prominence. Attention has been focused notably on the reticulocytes, the primitive types of blood cells that are an index of the response of the hematopoietic tissue of the bone marrow. It has been asserted that the fundamental defect in hematopoiesis during a relapse in pernicious anemia is due to the inability of the primitive red blood cells of bone marrow to differentiate normally into the adult state. When the regenerative activity of the bone marrow becomes restricted, the numbers of red blood cells in the peripheral blood decrease, and many of those present are abnormal. The liver, kidneys and stomach contain a substance that appears to stimulate the maturation of the primitive red blood cells and

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