Using a unique approach to screen hundreds of compounds, researchers at Boston Children’s Hospital and their colleagues have identified epoxyeicosatrienoic acids (EETs) as a family of lipids that can enhance stem cell engraftment in both zebrafish and mice (Li P et al. Nature. doi:10.1038/nature14569 [published online July 22, 2015]).
The team took advantage of a transparent mutant zebrafish line to compare engraftment of 2 fluorescently tagged marrow cell pools. A green fluorescent marrow cell pool was incubated with various compounds, while a red fluorescent cell pool was not. When the researchers injected a mixture of green and red marrow cells into recipient zebrafish, they could measure the green-red fluorescence ratio in the transplant recipients. Epoxyeicosatrienoic acids stood out as chemicals that increased engraftment, leading to a predominance of green marrow cells.
Hampton T. Lipid Molecules May Help Improve Bone Marrow Engraftment. JAMA. 2015;314(9):866. doi:10.1001/jama.2015.10608