In Reply Many of the clinical risk scores currently used in everyday practice have not been formally tested in prospective randomized clinical trials. Variability in INRs and TTR is dependent on many clinical risk factors,1 and the SAMe-TT2R2 score simply puts the more common clinical factors into a simple acronym for easy use in everyday clinical practice2 rather than relying on guesswork.
Lip GYH, Lane DA. Assessing Eligibility for Anticoagulation After Diagnosis of Atrial Fibrillation—Reply. JAMA. 2015;314(9):949-950. doi:10.1001/jama.2015.8995