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September 1, 2015

Body-Fixed Sensors for Parkinson Disease

Author Affiliations
  • 1Center for the Study of Movement, Cognition, and Mobility, Department of Neurology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
  • 2Department of Neurology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
  • 3Department of Physical Therapy, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
JAMA. 2015;314(9):873-874. doi:10.1001/jama.2015.8530

Patients with Parkinson disease experience a complex array of both motor and nonmotor symptoms. The traditional motor hallmarks of Parkinson disease include rigidity, bradykinesia, resting tremor, postural instability, and freezing of gait. As the disease progresses, treatment-related motor response fluctuations and involuntary movements appear. In addition, cognitive disturbances, disautonomia, affective difficulties, and sleep disturbances are also common and further challenge the assessment and treatment of the progressive course of Parkinson disease. Treatment in Parkinson disease is traditionally based on periodic clinical evaluation, reporting of symptoms during the office visit, home-based diaries, and clinical scales assessing motor state, activities of daily living, cognitive and affective state and quality of life. These methods are able to track long-term changes, however, they generally have limitations related to recall bias, subjective reporting, and accuracy. These tools are also insensitive to subtle changes in motor and nonmotor function and the common daily and weekly fluctuations. Better tools are needed to accurately and objectively track disease symptoms, fluctuations, progression, and the effect of treatments.

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