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October 16, 1926

THE RETICULO-ENDOTHELIAL SYSTEM AND THE ORIGIN OF PHAGOCYTIC CELLS

JAMA. 1926;87(16):1306-1307. doi:10.1001/jama.1926.02680160054019
Abstract

Conceptions of the mechanism of phagocytosis seem to vary with geographic location and the school of pathology with which the investigator may be affiliated. In a recent consideration of the source of phagocytic cells, Eliot4 points out that they have been assumed to take their origin in the reticulo-endothelial system. In the order of increasing phagocytic properties, as generally recognized, these cells include "ordinary endothelial cells, fibrocytes, reticular cells of the spleen and lymphoid tissues, the reticulo-endothelium of the spleen, lymph and marrow sinuses, of the lung, suprarenal and hypophysial capillaries, the Kupffer cells of the liver, the histiocytes or clasmatocytes, and the splenocytes and blood monocytes." 5 Eliot offers evidence, however, to prove that the reticulo-endothelial system is composed largely of phagocytic white blood cells. After ingesting particles of carmine, used as a test dye in these experiments, they seem to have migrated from the blood stream and

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