Tumors of the chorion have interested the profession for many years. Saenger1 in 1888 described the symptoms and diagnosis, and Fränkel2 and Marchand3 in 1895 demonstrated that the chorionic epithelium gave rise to these growths. In 1910 Ewing4 published his investigations on the prognosis of these growths based on a histologic study.
The difficulties of making a clinical and pathologic diagnosis of the diseases and the tumors of the chorion are great. The fact that under normal conditions syncytial wander cells are found in the decidua and the myometrium, and that some of the choriomas are composed of all the elements and others of only the epithelial cell elements of the trophoblast, are responsible for the difficulties in diagnosis.
Six cases of malignant chorionepitheliomas were observed in our clinic within a relatively short time. They were referred on account of severe uterine bleedings, while one case
SCHMITZ H, HUEPER W. MALIGNANT CHORIONEPITHELIOMA UTERI. JAMA. 1930;95(19):1413-1417. doi:10.1001/jama.1930.02720190025006