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November 8, 1930


JAMA. 1930;95(19):1428-1429. doi:10.1001/jama.1930.02720190040011

The first reference to agranulocytic angina seems to have been made in 1907, when Turk1 called attention to the low granulocyte count in some cases of severe sepsis. The suggestion apparently did not arouse interest until 1922, when Schultz2 described a number of cases which revealed an almost complete absence of granular cells associated with a group of symptoms and pathologic conditions which he declared formed a clinical entity. Later Friedemann3 named this group of cases "agranulocytic angina." The features emphasized by Schultz were a high fever, occurring generally in elderly women with necrotic throat infections, rapid exhaustion, slight jaundice frequently, leukopenia with few if any granular cells but no involvement of the red blood cells or platelets, and death within a short time in almost every case. After Schultz's work became known, case reports began to appear in medical literature everywhere; now more than 150 cases

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