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To the Editor:
—To one who has administered tincture of iodine in tuberculosis for a number of years, the reading of material on this subject in recent issues of The Journal has been of deep interest. Concerning the work done by H. W. Butler on guinea-pigs, to which Dr. Edwards (The Journal, August 14, p. 509) refers, particularly the one pig that received a single dose of tincture of iodine for fourteen days, it is questionable whether one-fifteenth grain (4 mg.) of iodine in a drop of tincture of iodine U. S. P., or the drop of pure alcohol, killed the pig. Every one who has done experimental work on guinea-pigs knows quite well that tincture of iodine cannot be given to guinea-pigs satisfactorily. The guinea-pig is extremely sensitive to the most minute quantities of alcohol, and alcohol administered to the animal in any form is highly and quickly toxic.
Ritter J. IODINE IN TUBERCULOSIS. JAMA. 1926;87(18):1498. doi:10.1001/jama.1926.02680180070030