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June 24, 1933


JAMA. 1933;100(25):2030. doi:10.1001/jama.1933.02740250052020

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Controversy Concerning the Nature of Bacteriophage  The discovery of d'Herelle concerning the existence of filtrable and living viruses that develop in bacterial cultures and are capable of producing bacteriolysis has always been the subject of controversies at the Institut Pasteur de Paris, where d'Herelle made his discovery. The clinical results are incontestable; but d'Herelle regards this lyzing principle as a living micro-organism, which he calls "bacteriophage," and supports his view on the fact that this principle can be cultivated indefinitely by transplanting in nutritive mediums and on the added fact that it is destroyed by heat. Innumerable observations have shown that the bacteriophage of the staphylococcus, when injected into the lesions of furuncles or anthrax, renders the pus sterile. The bacteriophage of cholera, when implanted in India in the wells of infected regions, has promptly arrested epidemics. Nevertheless, Professors Roux and Calmette, the directors of the Institut Pasteur de Paris,

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