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June 24, 1933

Cardiovascular Pain as a Biochemical Problem.

JAMA. 1933;100(25):2042. doi:10.1001/jama.1933.02740250064035

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Lambert makes no claim that he has settled the question of anginal, or, as he prefers to call it, cardiovascular, pain. His object is to show the weak spots in the prevailing theories and to urge a greater concentration of investigation on the possibility, or the probability, of a chemical explanation. He asserts that investigations based on morbid anatomy have not solved the problem, though he does not go so far as to rule out pathologic conditions of the heart and aorta as having something to do with the production of pain. The logic of the author is often loose. His pages contain too frequently such expressions as "impression," "suspicion," "assumed," "one ventures to suggest," "doubtless," "perhaps." In other words, there is a lack of proof based on clinical, anatomic or laboratory facts that seriously detracts from the value of the work. One may agree with the laudable desire to

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