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November 15, 1930


JAMA. 1930;95(20):1506-1507. doi:10.1001/jama.1930.02720200042013

It has been eighty years since Addison1 announced in London that a peculiar type of anemia associated with severe muscular weakness was related to a marked pathologic condition of the suprarenal glands. In an elaborate review of the accretions of knowledge in the intervening period regarding their possible functions and physiologic significance, Britton2 of the University of Virginia has made the comment that even in these days of ultraspecialized—it might be called high-powered—physiology, three fourths of a century later, little definite information of suprarenal activity beyond that of the secretion of epinephrine by one part of the gland has been acquired. There have been many disappointments, numerous errors of experiment and interpretation, and several acrimonious debates regarding the claims of discovery, until the casual student began to wonder whether the suprarenals should be put in a category with the spleen or the appendix or the gallbladder as structures

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