The infrequency of hemangio-endothelioma of the liver probably warrants reporting such a case, but its recognition as a medical entity is almost impossible and consequently detracts from its clinical interest.
There seems to have been some confusion in the classification of several types of sarcomas and angiomas of the liver, although there is a great similarity in the microscopic picture. One gets the impression from the various pathologic descriptions that probably all have their origin in the walls of the liver capillaries, with great proliferation of endothelial cells and even the formation of many new blood vessels. The cells are morphologically sarcomatous in type and must be considered malignant, although in many of the cases no metastases were found, possibly because of the early death of the patient. In some of the cases reported more recently, metastases were found in the lungs, pancreas and retroperitoneal glands. The tumors have been
White CS. PRIMARY HEMANGIO-ENDOTHELIOSARCOMA OF THE LIVER. JAMA. 1933;101(2):119–121. doi:10.1001/jama.1933.27430270001009a