A 32-year-old woman presented with headaches of increasing severity that began approximately 3 years ago. The headaches were severe enough to interfere with daily activities, occurred several times weekly, and were associated with nausea, vomiting, photophobia, and sensitivity to noise. She had no focal neurological symptoms. Funduscopic and neurologic examination results were normal. A diagnosis of migraine headaches was made, but therapeutic trials with nonsteroidal anti-inflammatory drugs and sumatriptan were unsuccessful. Routine blood counts were normal except for a platelet count of 665 × 103/μL (Table).
Schafer AI. Thrombocytosis. JAMA. 2015;314(11):1171-1172. doi:10.1001/jama.2015.8515