The clinical diagnosis of viability of a pregnancy, especially in the early months, is usually difficult. Both the Aschheim-Zondek1 and the Friedman2 pregnancy tests may be of considerable help in determining life or death of the fetus. As Wilson and Corner,3 Wladika4 and Spielman5 have demonstrated, these two reactions depend on the presence or absence of viable chorionic villi. With the complete death of the chorionic tissue, the tests become negative. The prepituitary hormone is the substance which here plays the important rôle.
Besides the prepituitary, the female sex hormone is also considerably increased in pregnancy from the second month on. As early as 1926, we6 called attention to the importance of female sex hormone studies in pathologic pregnancy. In order to determine a possible interrelationship between life or death of a fetus and both of these hormones, studies of the hormones were instituted
SPIELMAN F, GOLDBERGER MA, FRANK RT. HORMONE DIAGNOSIS OF VIABILITY OF PREGNANCY. JAMA. 1933;101(4):266-268. doi:10.1001/jama.1933.02740290014005