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July 22, 1933


Author Affiliations

From the Physiological Laboratories of the University of Chicago.

JAMA. 1933;101(4):275. doi:10.1001/jama.1933.27430290001010

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It is known that cases of acne vulgaris are improved temporarily by treatment with ultraviolet rays. The present work was based on the supposition that the activation of ergosterol in the skin by ultraviolet rays is the prime factor for this temporary relief in acne. We therefore attempted to alleviate acne by the direct ingestion of vitamin D in the form of viosterol.

We ourselves were our first patients, since both of us have this condition. We started with a dosage of 10 drops a day of Mead's viosterol in oil 250 D and increased this during a period of two weeks to 20 drops a day. After continuing for a period of one month we observed by actual count of pustules a decrease of about 75 or 80 per cent. We considered these results satisfactory enough to warrant experimentation on a larger number of subjects.

The subjects chosen for

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