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The experimental Ebola vaccine rVSV-ZEBOV may offer highly effective and rapid protection against the virus with a single injection, according to the first interim results reported from the Ebola ça Suffit cluster randomized phase 3 trial conducted in Guinea (Henao-Restrepo AM et al. Lancet. doi:10.1016/S0140-6736(15)61117-5 [published online August 3, 2015]).
The trial, sponsored and led by the World Health Organization, used a ring vaccination strategy that did not include a placebo control group. According to the researchers, such a cluster or ring vaccination approach can be effective in resource-poor countries where the incidence of Ebola is low in the general population.
Slomski A. Single Dose of Ebola Vaccine May Be Protective. JAMA. 2015;314(12):1217. doi:10.1001/jama.2015.11778