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Dr. Clovis Corrêa reports in the Revista de gynecologia e de obstetricia, May, 1932, observations on twenty-five cases of chronic hypertrophic ulcer of the vulva, which was usually found on the labia. The anorectal region was frequently affected, always resulting in stricture of the rectum. The ulcers had punched-out, undermined borders and an irregular bottom. Often there were long fistulous tracts, edema and infiltration of the labia majora resembling elephantiasis. The anal sphincter may be destroyed. The etiology is much discussed. Race does not seem to be important. Among thirty-three patients Corrêa has found sixteen white, eleven mulatto and six Negro women. He questions whether his cases were not a form of lymphogranulomatosis. Histopathologic examination has revealed elements similar to those of the primary lesion of Nicolas-Favre disease. Frei's reaction by intradermic injection of diluted pus of the bubo of lymphogranulomatosis was positive. The initial venereal chancre must have
RIO DE JANEIRO. JAMA. 1933;101(5):383. doi:10.1001/jama.1933.02740300051026