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In this treatise, Reding has accumulated the available evidence in support of the theory that cancer is primarily a constitutional disease. To the evidence gathered in the literature the author has added his own investigations, the results of which support this view. The susceptibility of some animals to tar and the immunity of others are indicated as an example of an underlying constitutional predisposition. Variations in racial susceptibility in animal and man are interpreted in a similar manner, as is also hereditary predisposition and resistance. The author maintains that physicochemical changes in the cancerous organism are found in the precancerous state and persist after surgical extirpation of the lesion. These facts are interpreted as indicating that these changes are an integral part of the general predisposition. In almost all cancer patients the author discovered a more or less serious disturbance of sugar metabolism. Alkalosis of the plasma, a diminution in
Le terrain cancéreux et cancérisable; Physiologie pathologique du cancer. Action biologique des radiations.. JAMA. 1933;101(5):394. doi:10.1001/jama.1933.02740300062040