In 1923, the attention of the United States Radium Corporation was called to the possible existence of an industrial hazard in its plant at Orange, N. J., by the statements of a dentist, who suggested that the condition of one of his patients might be due to previous industrial exposure there.
During the last four years, there have been five deaths among former employees of this plant who had been engaged in painting the dials of instruments with luminous paint. Pathologic observations in these cases, and in those of one or two other employees of the company, call for an explanation as to their causes.
The pathologic conditions consisted of a necrosis of the jaw, which had been observed to follow the removal of a tooth or dental intervention of some other kind, accompanied by severe anemia terminating in death. After such dental intervention, there developed a very rapid form
FLINN FB. RADIOACTIVE MATERIAL AN INDUSTRIAL HAZARD?. JAMA. 1926;87(25):2078–2081. doi:10.1001/jama.1926.02680250036010