In a review of the functional significance of the gallbladder, Mann1 has remarked that the justification for such a discussion lies not so much in what is actually known concerning the functions of this exceptional organ as in what has been imagined concerning its functions. From time to time reference has been made in The Journal2 to the shifting views and new investigations that might modify the current doctrines. Thus, the alleged significance of the so-called valves of Heister was debated, with the conclusion that they cannot be considered of major importance with regard to the general physiology of the gallbladder. Our knowledge of the changes that bile may undergo in this organ has been considerably augmented in recent years. There can be little doubt of the occurrence of absorption of water in it, with a consequent concentration of the bladder bile.
The problem of the motor mechanism
THE MECHANISM OF THE GALLBLADDER. JAMA. 1927;88(1):32-33. doi:10.1001/jama.1927.02680270032010