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September 2, 1933


Author Affiliations


JAMA. 1933;101(10):753-756. doi:10.1001/jama.1933.02740350011003

In 1924 we1 described the presence of scarlet fever toxin in the blood of certain patients with scarlet fever. This observation was confirmed by Cooke.2 The toxin was demonstrated by the intracutaneous injection of patients' serum into a group of human volunteers composed of four persons whose serum failed to blanch the rash in scarlet fever and of four whose serum blanched the rash. Those whose serum failed to blanch the rash served as test subjects and the other four as controls. Subsequently, Dick tests were done on the group of volunteers. The test subjects gave positive reactions to the Dick test, and the controls, negative reactions. The reactions elicited by the serums and the Dick tests were similar. The toxin in the patients' serums was shown to be neutralizable both by natural human antitoxin and by artificially produced horse antitoxin. Heterogenicity among the toxins was not observed,

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