Clinically, hydatidiform mole is suspected in cases of bleeding during the first trimester of pregnancy, associated with disproportionate enlargement of the uterus.1 In pregnancy, of course, rest and waiting are the prescribed treatment for bleeding. In hydatidiform mole, the uterus should be emptied immediately, irradiated, and possibly removed.
Hormone studies from several sources recently have indicated another diagnostic point: in hydatidiform mole and chorionepithelioma there is a greatly increased concentration of anterior pituitary sex hormone in the urine.2 Mazer and Goldstein3 say:
"Aschheim obtained a positive pregnancy reaction in a case of hydatidiform mole with one-twelfth the amount of urine usually necessary to secure such a reaction. Reeb states that the amount of anterior pituitary hormone excreted in cases of hydatidiform mole and chorionepithelioma is from 10 to 500 times that excreted during normal pregnancy.... In cases of bleeding during the first trimester of pregnancy associated with
Dabney MY, Flinn GG, Dabney EB. DIFFERENTIATION OF PREGNANCY AND HYDATIDIFORM MOLE. JAMA. 1933;101(10):771-772. doi:10.1001/jama.1933.27430350001008a