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January 15, 1927

L'enfant issu de parents tuberculeux.

JAMA. 1927;88(3):196. doi:10.1001/jama.1927.02680290058036

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This is essentially a study of the fate of the child of tuberculous parents; also an elaborate criticism of a renaissance of the theory of the intra-uterine infection of the embryo with the tubercle bacillus. Lelong deals thoroughly and fairly with the proponents of infection of ovule and spermatozoon. Tuberculosis of the placenta is accepted as happening on rare occasions, but is characterized as being most unusual. The actual discovery of tubercle bacilli in the placental tissue is cited but not confirmed by careful sectioning or by guinea-pig inoculation. The case of tuberculosis of the placenta, he states, can never be shown macroscopically or microscopically, except in rare instances. Lelong agrees that antibodies originating in the maternal system may be passed to the fetal system, but disappear from the infantile system in a few weeks. The author's studies of cadavers of children born of tuberculous mothers fail to show evidence

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